Rethymno sits right in the middle of the two main airports (Heraklion and Chania), that means that there are many fight options to choose from.
If a ride is needed from the airports to your accommodation click here.
It is also possible to take one of the daily ferries from Athens straight to the heart of Rethymno, from where it is just a few meters to the old town.
There is of course the option to rent a car to be as adaptable as possible.
If self-driving isn’t an option there is a frequent bus system which connects Rethymno with other towns and villages or use the local taxi services.